It is injected subcutaneous every 3 months. Same siRNA type drug as Patisiran. It stop production of the protein in the liver. It supposedly has fewer side-effects because it is not an infusion drug, and is administered only every 3 months. It may not be a Medicare covered expense in the same way as Patisiran is, due to it not being an infusion given in an FDA approved infusion center. Not sure about that cost issue.

I am on Amvuttra and it's so much better than the infusion for me. I was having side effects from the pre-meds. It's covered through my insurance: Empire also called United Health Care and my Medicare Parts A&B. I also get a copay assistance from the company that produces the medication: Alnylam https://www.alnylam.com
They provide an Education Liaison that help you to understand who the medication works and also information about genetic counseling and their copay assistance program. I feel so fortunate to be on this medication it has improved my quality of life.

Here is a more detailed response...

Both are of the same drug class and mechanism of action:
binds to transthyretin (TTR) mRNA, reducing serum TTR protein and deposits in tissues (small interfering ribonucleic acid).

Amvuttra is a subcutaneous injection every 3 months rather than IV infusion every 3 weeks. With both drugs, patient must take vitamin A supplement while on it therapy.

Amvuttra has similar drug coverage under Medicare as it is billed as a procedure rather than a drug under Part-D.

Amvuttra has much better side effect profile and is much better tolerated.

Onpattro (Patisirin) infusion must be preceeded 60min prior with prophylatic IV corticosteroid (dexamethasone) for infusion reactions, IV H1-blocker (diphenhydramine/benadryl) for infusion reactions, oral tylenol/acetaminophen for infusion reactions, and IV H2-blocker (pepcid) to protect stomach.

Repeated IV steroids leads to its own side effects over time (bone deterioration that leads to osteoporosis, hyperglycemia that leads to Diabetes, elevated white blood cell count/leukocytosis increasing infection risk, etc).

Furthermore, with Patisirin therapy a patient should be monitored regularly to include kidney function and blood counts. This is not necessary with Amvuttra.

My mother is on Amvuttra as first line. I strongly avoided having her put on Patisirin due to her other comorbidities and hassle/frequency of drug administration.

Onpattro/Patisirin:
https://acrobat.adobe.com/link/review?uri=urn:a...

Amvuttra/Vutrisiran:
https://acrobat.adobe.com/link/review?uri=urn:a...

(Yes, in case you're wondering, I have a medical background 😉)

Very well said.😊My husband is doing pretty good except for weight lossAND edema in legs. We are living a blessed life

My husband has had no copay with Amvuttra .Analym Assist has covered the cost