I agree with Alain. I likely began experiencing early symptoms of my wild-type amyloidosis at least 20-years ago.

About your question related to Carpal tunnel and ATTR, I can say that personally, I have W-ATTR-cm, I was even heart transplanted. I had carpal tunnel in the two wrists, but it was about 20 to 30 years before having any symptoms of amyloidosis… I was even operated to each of my ten fingers for Trigger fingers. At that time, relationship between amyloidosis and carpal tunnel wasn’t established, So, it seems to me that the progression of amyloidosis is very slow and extends over many years and even decades. But I’m just a patient, not a specialist !

Joseph, it may not buildup in your heart sufficiently enough for it to become a significant health issue. My understanding from you is that you do have some amyloid fibrills excellularly deposited in your heart but only very slightly.