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Does Tafamidas And Diffusional Do The Same Have Wild Type

A MyAmyloidosisTeam Member asked a question 💭
Detroit, MI
October 5
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A MyAmyloidosisTeam Member

Pfizer developed Tafadamis by studying and mimicking Diflusinal

October 5
A MyAmyloidosisTeam Member

I'm doing okay, thanks Joe. I hope you're doing well.

October 5
A MyAmyloidosisTeam Member

How are you Sheldon?---Joe

October 5
A MyAmyloidosisTeam Member

Tafamidis and diflunisal are both used to treat wild-type amyloidosis, but they work differently:

- Tafamidis: FDA-approved to treat heart disease in wild-type amyloidosis. It stabilizes the TTR protein, preventing amyloid fibril formation
- Diflunisal: Used off-label for amyloidosis. It works similarly to tafamidis by Show Full Answer

Tafamidis and diflunisal are both used to treat wild-type amyloidosis, but they work differently:

- Tafamidis: FDA-approved to treat heart disease in wild-type amyloidosis. It stabilizes the TTR protein, preventing amyloid fibril formation.
- Diflunisal: Used off-label for amyloidosis. It works similarly to tafamidis by stabilizing TTR proteins, but it is not officially approved for this use.

Both can help improve survival rates and quality of life for people with wild-type amyloidosis.

October 5

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