Not medical advice, but I fly fairly frequently (2-3 hours tops) with pretty advanced heart failure due to AL. Importantly, I’m on Eliquis, so far less likely to experience DVT, etc. I would not fly if advised by cardiologist not to do so.

Ask a third one to break the tie 🤷🏻‍♀️ then with all the info do what’s right for you

My husband has W-ATTR, and we cautiously went on an African safari in July and it was amazing. We were prepared with spectacular travel insurance just in case, and the level of walking was pretty minimal. So it was a really good fit for him at this point. We hope to see more wild places while he can, as long as he can. When he goes on birding trips, I go on a hiking trip so I can try to maintain my hiking function without frustrating him. Taking it one year at a time and trying to just be grateful for what we CAN do, instead of focusing on what we can't. It's a work in progress!