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Does a negative attr gene test mean i have wild type?

A MyAmyloidosisTeam Member asked a question 💭
Sacramento, CA
September 14, 2024
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Reactions
A MyAmyloidosisTeam Member

thanks, Sheldon. I was waiting for your answer… Yes, I had a negative AL test so I’m assuming wild type. Continued prayers for everyone.

September 14, 2024
A MyAmyloidosisTeam Member

Genetic testing for hereditary ATTR otherwise known as hATTR or vATTR, that yields a negative result for all 130 genome responsible for hATTR, may mean that you either have wtATTR or AL Amyloidosis. A Kappa/Lamda blood test and a 24-hour urine test for light proteins can rule out AL Amyloidosis. Then you know with certainty that you have wtATTR.

September 14, 2024
A MyAmyloidosisTeam Member

I have biopsy-proven Cardiac AL. Urine has always been negative, as was fat-pad (abdominal) aspirate.

September 23, 2024
MyAmyloidosisTeam

A negative ATTR gene test does not automatically mean you have wild-type ATTR amyloidosis. Here's a detailed explanation:

- Testing Process
- If a protein sequence analysis test on a biopsy sample shows that the TTR protein is involved, a blood sample is sent for a genetic-sequencing test to examine the DNA chains.
- Show Full Answer

A negative ATTR gene test does not automatically mean you have wild-type ATTR amyloidosis. Here's a detailed explanation:

- Testing Process:
- If a protein sequence analysis test on a biopsy sample shows that the TTR protein is involved, a blood sample is sent for a genetic-sequencing test to examine the DNA chains.
- If this genetic-sequencing test produces no identifiable mutations, then wild-type ATTR amyloidosis is the resulting diagnosis.

- Other Tests:
- Doctors may also perform other laboratory tests, including blood or urine tests, to determine whether the organs are working correctly.
- Certain blood tests may be used to track amyloidosis.

In summary, a negative ATTR gene test is a significant step towards diagnosing wild-type ATTR amyloidosis, but additional tests and evaluations are typically required to confirm the diagnosis.

September 14, 2024
A MyAmyloidosisTeam Member

love it!!! stay wild

September 23, 2024

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