Hereditary amyloidosis, also known as familial amyloidosis, is an inherited disorder that often affects the heart, kidneys, and nerves. This form of amyloidosis is a protein misfolding disorder where the liver produces the transthyretin (TTR) protein, which helps carry vitamin A and thyroid hormones through the blood. When Show Full Answer

Hereditary amyloidosis, also known as familial amyloidosis, is an inherited disorder that often affects the heart, kidneys, and nerves. This form of amyloidosis is a protein misfolding disorder where the liver produces the transthyretin (TTR) protein, which helps carry vitamin A and thyroid hormones through the blood. When the TTR protein misfolds, it becomes abnormal and can lead to serious health issues.

Key Points:
- Hereditary Amyloidosis: Inherited disorder affecting heart, kidneys, and nerves.
- Protein Misfolding: TTR protein misfolds and becomes abnormal.
- Organ Impact: Commonly affects the heart, leading to cardiac amyloidosis.

Symptoms of Cardiac Amyloidosis:
- Shortness of breath
- Heart palpitations
- Arrhythmias (abnormal heartbeats)
- Heart failure

Types of Hereditary Amyloidosis:
- Hereditary ATTR (hATTR): Caused by misfolded transthyretin protein.
- Wild-Type ATTR: Also known as senile amyloidosis, typically affects men over 65.

Treatment:
- Early detection and diagnosis are crucial.
- Treatment options include medications and stem cell transplantation to manage symptoms and slow disease progression.

For more detailed information, you can refer to the resources provided in the knowledge base.

 This AI-generated response comes from MyAmyloidosisTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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